Inflammation induced by degenerative lumbar scoliosis
10.3969/j.issn.2095-4344.2016.07.017
- VernacularTitle:退行性腰椎侧凸的炎症反应
- Author:
Ningbo MENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(7):1031-1036
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:Degenerative lumbar scoliosis patients wil appear to have abnormal changes in various cytokines in the serum of the body, which is closely related to patient’s pathogenesis.
OBJECTIVE: To monitor the changes in the serum levels of tumor necrosis factor-α, interleukin-6 and interleukin-1β during the onset of degenerative lumbar scoliosis.
METHODS: Sixty-six patients with degenerative lumbar scoliosis were enrolled as observation group, and according to Schwab evaluation system, there were 16 cases of type I, 32 of type II, and 18 of type III. Additionally, 60 healthy persons undergoing homochronous physical examination were extracted as control group. Blood samples were taken at preoperative 1, 2, 3 weeks and at postoperative 1, 2, 3, 4, 5, 6 weeks to determine serum levels of tumor necrosis factor-α, interleukin-6 and interleukin-1β as well as to observe the relevant changes.
RESULTS AND CONCLUSION:In the observation group, the levels of tumor necrosis factor-α, interleukin-6 and interleukin-1β were increased gradualy at 1-3 weeks before treatment, and then showed a decrease trend at 6 weeks after treatment. Compared with the control group, in the observation group, the levels of tumor necrosis factor-α were significantly higher at 1-4 weeks after admission (P < 0.05); the levels of interleukin-6 and interleukin-1β were significantly higher at 1-5 weeks after admission (P < 0.05). These findings indicate that the levels of tumor necrosis factor-α, interleukin-6 and interleukin-1 reached the peak at 1 week before treatment, and then gradualy decreased. Changes in the levels of tumor necrosis factor-α, interleukin-6 and interleukin-1β have an important role to assess disease development, which can be used to determine the severity of inflammation based on which we can select the appropriate treatment.
