Tissue-engineered cartilage for repair of sports-induced cartilage injury
10.3969/j.issn.2095-4344.2016.07.018
- VernacularTitle:组织工程化软骨修复运动性软骨损伤
- Author:
Dapeng WANG
;
Lan ZHANG
;
Na ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(7):1037-1043
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Sports-induced cartilage injury is very common; due to the poor self-healing capacity of the cartilage, cartilage repair has always been a difficult problem.
OBJECTIVE: To review the features of different seed cels in tissue-engineered cartilage construction and to explore the application of tissue-engineered cartilage construction in the repair of sports-induced cartilage injuryin vitro.
METHODS:We searched PubMed database, Wanfang database and CNKI database for articles related to tissue-engineered cartilage repair of sports-induced cartilage injuries, as wel as stem cels and scaffold materials used in tissue-engineered cartilage construction. Totaly 190 articles were retrieved, and finaly 47 articles were included in result analysis after repetitive studies were excluded.
RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cels under different conditions can differentiate into chondrocytes, and have better potential of chondrogenic differentiation compared with adipose-derived mesenchymal stem cels and umbilical cord-derived mesenchymal stem cels. But, their safety stil needs to be further studied. Good scaffolds cannot only induce stem cel differentiation, but also be the key to cartilage construction. Composite materials are the future direction of the scaffold research.
