Effects of Qiliqiangxin capsule on serum concentration of adiponectin and heart function in patients with ;uremia combined with heart failure
10.3969/j.issn.1006-5725.2016.05.037
- VernacularTitle:芪苈强心胶囊对尿毒症合并心力衰竭患者血清脂联素及心功能的影响
- Author:
Xin CHEN
;
Qi LIU
;
Jin LIU
- Publication Type:Journal Article
- Keywords:
Uremia;
Qiliqiangxin capsule;
APN;
Heart function
- From:
The Journal of Practical Medicine
2016;32(5):809-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Qiliqiangxin capsule on serum concentration of adiponectin (APN) and heart function in patients with uremia combined with heart failure. Methods Uremia patients combined with heart failure were randomly divided into treatment group and control group , both of which were given anti-failure routine therapy. The patients in treatment group were treated with Qiliqiangxin capsule for 8 weeks and those in control group with placebo. The New York Heart Association (NYHA) heart function classi-fication, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction(LVEF), and the levels of APN were observed before and after treatment. Results The level of APN in uremic patients combined with heart failure was significantly higher than that in normal subjects. With the increase in the class of NYHA heart function, the serum concentrations of APN increased, but the difference was not significant(P > 0.05). After 8 weeks′ treatment, the effective rate in treatment group was higher than that in control group (P < 0.05). LVEDD and LVESD in both groups decreased significantly. LVEF in both groups increased, but serum concentration of APN decreased significantly. More obvious effects were observed in treatment group (P < 0.05). Conclution Qiliqiangxin capsule could significantly reduce the level of APN and improve heart function in patients with uremia combined with heart failure.
