Curative effect of recombinant tissue plasminogen activator in acute ischemic stroke patients in more than ;15 points of NIHSS scores and less than 4.5 h in onset time
10.3969/j.issn.1006-5725.2016.05.038
- VernacularTitle:NIHSS评分≥15分且发病时间≤4．5 h的重型脑梗死患者静脉溶栓的疗效观察
- Author:
Yanfei TONG
;
Peilan ZHANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
NIHSS score;
Recombinant tissue plasminogen activator;
Alteplase
- From:
The Journal of Practical Medicine
2016;32(5):812-815
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effect and safety of recombinant tissue plasminogen acti-vator (rt-PA) in acute ischemic stroke (AIS) patients in more than 15 points of NIHSS scores and less than 4.5 h in onset time. Methods One hundred and twenty-seven cases with AIS in more than 15 points of NIHSS scores and less than 4.5 h in onset time were included into the study. According to the patients′ option to accept the intravenous thrombolytic therapy , 68 patients received intravenous thrombolysis with alteplase as the treat-ment group, 59 patients did not receive intravenous thrombolytic therapy as the control group. The incidence of intracerebral hemorrhage and mortality were observed in the two groups after thrombolytic therapy. Their nerve function defect was scored according to the NIHSS scores before and after treatment at day 7 and day 30. Their living ability was assessed by mRS in modified Rankin chart after the treatment at the day 90. Results The NIHSS scores were significant lower in the 2 groups after therapy (P < 0.05). The NIHSS scores at each time point and mRS scores in the treatment group were lower than the control group (P < 0.05). No significant differ-ence was found in the incidence of intracerebral hemorrhage and mortality between the 2 groups , although these were higher in the treatment group than in control group (1.5% vs 0%, 7.5% vs 5.1%, P > 0.05). Conclusion Intravenous rt-PA thrombolytic therapy is effective and safe for AIS whose NIHSS scores are more than 15 points and onset time are less than 4.5 h.
