Effect of Yang-Xue Qing-Nao Granules on Protein Expression of BDNF and bFGF in CA1 Area of Hippocampus among Vascular Dementia Rats
10.11842/wst.2015.11.011
- VernacularTitle:养血清脑颗粒对血管性痴呆大鼠海马CA1区BDNF和bFGF蛋白表达的影响
- Author:
Jinxia ZHANG
;
Yunkun SAN
;
Jing LI
;
Yuanyuan MA
;
Bin LIU
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
brain-derived neurotrophic factor;
basic fibroblast growth factor;
Yang-Xue Qing-Nao granules
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(11):2246-2251
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the effect of Yang-Xue Qing-Nao(YXQN) granules on the expression of brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (bFGF) in CA1area of hippocampus among vascular dementia (VD) rats.A total of 72 SD rats were randomly divided into the sham operation group,VD model group (model group) and YXQN treatment group (treatment group).The VD rat model was prepared by modified Pulsineli's four-vessel occlusion.The learning and memory abilities of rats were detected by the Morris water maze.The protein expressions of BDNF and bFGF were detected by the immunohistochemical analysis.The results showed that compared with the sham operation group,there was obvious learning and memory disorders in the model group with increased protein expressions of BDNF and bFGF in CA1 area of hippocampus at difference time points (P<0.01).Compared with the model group,the learning and memory abilities of rats in the treatment group were significantly improved; and the protein expressions of BDNF and bFGF in CA1 area of hippocampus were significantly increased at difference time points (P<0.01).The expression was the highest on the 4th week.It was concluded that YXQN granules can improve the learning and memory abilities of VD rats.Its mechanism may be related to the upregulation of protein expression of BDNF and bFGF.
