Dose-response Relation and Synergy Effects of Bioactive Components in Ginkgo biloba on Antiplatelet Aggregation and DPPH Free Radical Scavenging
10.11842/wst.2015.11.031
- VernacularTitle:银杏叶有效成分抗血小板聚集和清除DPPH自由基的量效关系和协同作用
- Author:
Jiawei REN
;
Yu SONG
- Publication Type:Journal Article
- Keywords:
Ginkgolide;
ginkgo flavonoids;
antiplatelet aggregation;
antioxidation;
dose-response relation;
synergy effect
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(11):2367-2372
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the dose-response relations and synergy effects of bioactive components in Ginkgo bilobaon antiplatelet aggregation and DPPH free radical scavenging.The antiplatelet aggregation experiment and DPPH free radical scavenging experiment were conducted respectively to investigate the dose-response relations and synergy effects.Firstly,the effect of inhibiting platelet aggregation induced by PAF of ginkgolides in rabbits was investigated.And then,the effect of DPPH free radical scavenging by ginkgo flavonoids was also investigated.Finally,the synergy effects among effective components were studied.The results showed that ginkgolide A,ginkgolide B,ginkgolide C and bilobalide had dose-response relations on antiplatelet aggregation.Quercetin,kaempferol and isorhamnetin had DPPH free radical scavenging effects with dose-response relation.It was concluded that ginkgolide had the dose-response relation on antiplatelet aggregation.Ginkgolide A and ginkgolide B had synergy effect.Ginkgo flavonoids had DPPH free radical scavenging effect.Quercetin and isorhamnetin had synergy effect.
