Retrospective analysis of cytogenetic abnormalities detected by fluorescence in situ hybridization in pa-tients with multiple myeloma

VernacularTitle:多发性骨髓瘤患者荧光原位杂交检测遗传学异常的回顾性分析
Author: Ke CAI ; Hongming HUANG ; Yanan MA ; Shenhua JIANG ; Runsheng DING ; Wei LU ; Yi SHEN ; Zhongwei SUN ; Yan WU
Publication Type:Journal Article
Keywords: Multiple myeloma; Fluorescence in situ hybridization; Cytogenetic abnormalities
From: The Journal of Practical Medicine 2016;32(5):778-781
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of the cytogenetic abnormalities detected by FISH in patients with MM and their clinical features. Methods FISH on bone marrow (BM) cells was performed in 57 enrolled MM patients. Relationships between cytogenetic abnormalities and clinical features were analyzed. Results By statistical analysis , both D13S319 deletion and RB1 deletion were associated with high level of serum LDH (P = 0.024; P = 0.018) and BM plasma cells index (P = 0.027; P = 0.013). 1q21 amplification was significantly associated with high level of LDH (P = 0.030 ) and the occurence of light chain type myeloma (P = 0.023). IgH rearrangement was associated with renal function damage (P = 0.009). There were correlations among D13S319 deletion, RB1 deletion, 1q21 amplification and IgH rearrangement (P<0.01). Conclusion The genetic abnormalities detected by FISH in patients with MM were correlated with various clinical poor prognostic indicators, which can evaluate the condition and prognosis of patients more efficiently.