The effect of quercetin in the rats of LPS-induced acute Lung Injury
10.3969/j.issn.1006-5725.2016.04.007
- VernacularTitle:槲皮素对内毒素诱导急性肺损伤大鼠的作用机制
- Author:
Haibo TANG
;
Ping YANG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Quercetin;
LPS;
Inflammation;
JAK2/STAT3
- From:
The Journal of Practical Medicine
2016;32(4):531-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and mechanism of quercetin in LPS-induced acute lung injury. Methods The PaO2, PaCO2, RR and pH, the expression of IL-6、 IL-1β、 TNF-α、 JAK2、 STAT3、 p-JAK2、 p-STAT3, the pathological change and Dry/Wet of Lung tissues were evaluated in rats. Results Quercetin can significantly decrease the pathological change of Lung tissues, the PaCO2, RR and the expression of IL-6、IL-1β、 TNF-α、 p-JAK2 and p-STAT3 with increasing the PaO2, pH and D/W. Therefore, with on influence on the expression of JAK2. Conclusion Quercetin pretreatment decreased LPS-induced acute lung injury by suppressing JAK2/STATA3 signallingto improve exchange ability though reducing inflammation.
