CD4+CD25+CD127low/- regulatory T cells and related cytokines in patients with psoriasis vulgaris

VernacularTitle:CD4＋CD25＋CD127low／－调节性T细胞在寻常型银屑病发病机制中的作用
Author: Congjun JIANG ; Shuo LI ; Jing ZHU ; Fang XIE ; Huiling JIN
Publication Type:Journal Article
Keywords: Psoriasis vulgaris; CD4+CD25+CD127low/-regulatory T cells; Interleukin-10; Transforming growth factor-β1
From: The Journal of Practical Medicine 2016;32(4):541-544
CountryChina
Language:Chinese
Abstract: Objective To explore the role of CD4+CD25+CD127low/-regulatory T cells (Tregs) in the pathogenesis of psoriasis vulgaris(PV). Methods Flow cytometry analysis was used to detect the amount of Tregs in peripheral blood and ELISA to test the levels of IL-10 and TGF-β1 in blood serum; the suppressive function of Tregs on autologous CD4+CD25-T cells was determined by MTT method. Results No significant difference was found in the proportion of Tregs in PV patients and healthy controls(P>0.05). There was a diminished suppression of Tregs from patients on autologous CD4+CD25- responder T cell proliferation in PV patients when compared with that in controls (P < 0.01). The serum level of IL-10 in patients was lower than that in controls (P < 0.01) while that of TGF-β1 in PV patients was significantly higher than that in controls(P < 0.01). Conclusion Abnormal function of Tregs and low secretion of IL-10 in PV patients might be related to the pathogenesis of psoriasis.