mRNA expression of silent information regulator 6 among population in Bama county of Guangxi
10.3969/j.issn.1006-5725.2016.04.012
- VernacularTitle:广西巴马地区长寿人群沉默信号调节蛋白6基因mRNA的表达
- Author:
Meiyu JIANG
;
Qianqian HUANG
;
Liwei SHI
;
Tianlong XIA
;
Xue LIANG
;
Min HE
;
Zhiyong ZHANG
;
Jian QIN
;
Xiao WEI
- Publication Type:Journal Article
- Keywords:
Bama;
Longevity;
Silent information regulator 6;
mRNA
- From:
The Journal of Practical Medicine
2016;32(4):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze mRNA expression of silent information regulator 6 (SIRT6) gene in the blood of population with family history of longevity in Bama county of Guangxi and to explore its association with SIRT6 gene polymorphism and its protein Methods One hundred and thirty-seven people (aged 30 ~ 106, 70 males, 67 females, 6.57% Han nationality, 93.43% Zhuang and Yao nationalities) with family history of longevity (long-lived family history group), and 91 people (aged 22~89, 51 males, 40 females, all Zhuang and Yao nationalities) without family history of longevity were recruited in the study (non-long-lived family history group). Real-time fluorescence quantitative RT-PCR was used to detect mRNA expression of SIRT6 gene in two groups. Results SIRT6 mRNA expression of total and femals in long-lived family history group were higher than those in non-long-lived family history group (P<0.05). mRNA expression of GG and CG genotype of SIRT6 (rs350846) and G allele carriers in long-lived family history group were all higher than those in non-long-lived family history group and the difference was statistically significant (P<0.05). SIRT6 mRNA expression was not associated with serum SIRT6 protein in long-lived family history group (P>0.05). Conclusion The expression of mRNA in SIRT6 gene may be associated with familial aggregation of longevity in Bama County of Guangxi and high expression of mRNA of SIRT6 in G allele carriers contributes to longevity.
