Analysis of serum insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with impaired glucose regulation and benign prostate hypertrophy
10.3969/j.issn.1006-5725.2016.04.018
- VernacularTitle:糖调节受损伴良性前列腺增生患者血清IGF-1、IGFBP-3的水平
- Author:
Zhaopeng WANG
;
Jun LI
;
Miao WANG
;
Jie HE
;
Min LIU
;
Yiwei WANG
;
Jian ZHOU
- Publication Type:Journal Article
- Keywords:
Impaired glucose regulation;
Benign prostate hypertrophy;
Insulin-like growth fator-1;
Insulin-like growth factor binding protein-3
- From:
The Journal of Practical Medicine
2016;32(4):569-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between IGF-1, IGFBP-3 and prostatic volume (PV) by examining the levels of insulin and insulin-like growth fator-1 (IGF-1) and insulin-like growth factor binding protein-3 ( IGFBP-3 ) and other indicators in patients with impaired glucose regulation and benign prostate hypertrophy. Methods According to 75 g oral glucose tolerance test (OGTT) results, 109 BPH patients aged over 50 years were divided into three groups: normal glucose tolerance (NGT) group (n = 56), impaired fasting glucose (IFG) group (n = 14), impaired glucose tolerance (IGT group, n = 39). The biochemical indicators and postatic hyperplasia related factors and IGF-1, GFBP-3 were measured. Results There were no statistical differences between the three groups in terms of blood lipids, homocysteine, urinary inhibition C, fasting insulin (FINS), glycosylated hemoglobin, IGF-1 and IGFBP-3 (P > 0.05). There were no significant differences between the groups in terms of PV, prostate specific antigen, the quality of life score and the international prostate symptom score (P > 0.05). Fasting plasma glucose and insulin resistance index (HOMA IR) were higher in IFG group than NGT group (P′ < 0.017) and IGT group (P′ < 0.017). 2-hour plasma glucose and 2-hour insulin were higher in IGT group than NGT group (P′ < 0.017) and IFG group (P′ < 0.017). PV was positively correlated with FINS but not correlated with IGF-1, IGFBP- 3 by multiple multiple step wise regression analysis. Conclusion Oyperinsulinemia is a risk factor in the development of BPH with IGR, and IGF-1 and IGFBP-3 are not associated with BPH risk. Further investigation is needed to elucidate the role of the IGF-1 and IGFBP-3 in BPH.
