Artifactual Hyperbilirubinemia due to Paraprotein Interference in a Case of Multiple Myeloma.
- Author:
Jae Yun JANG
1
;
Hanjun KIM
;
Young UH
;
Juwon KIM
;
Kap Jun YOON
;
Moon Young KIM
;
Jee Hyun KONG
Author Information
1. Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. u931018@yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Hyperbilirubinemia;
Paraproteinemias;
Positive bias;
Chemical analyzer
- MeSH:
Bilirubin;
Humans;
Hyperbilirubinemia*;
Multiple Myeloma*;
Paraproteinemias;
Paraproteins
- From:Journal of Laboratory Medicine and Quality Assurance
2013;35(2):133-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
When analyzing samples containing paraproteins, various interference effects are encountered in the clinical laboratory. Precipitation of paraproteins mostly interferes with the assays that use photometric detection. Herein, we present a case of a patient with multiple myeloma who had paraproteins and spuriously elevated total bilirubin levels (31.1 mg/dL), which were measured by using Roche total bilirubin assay on the Modular DPE (Roche Diagnostics, Switzerland) chemical analyzer. The total bilirubin concentration reduced from 31.1 mg/dL to 1.5 mg/dL, when tested after three fold dilution of the sample on Modular DPE chemical analyzer.
