Clinical study ofFuzi-Lizhongdecoction for diarrhea irritable bowel syndrome with Chinese pattern of spleen kidney yang deficiency
10.3760/cma.j.issn.1673-4246.2016.04.012
- VernacularTitle:附子理中汤治疗腹泻型肠易激综合征脾肾阳虚证临床研究
- Author:
Rihui CHEN
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Spleen-kidney yang deficiency;
Syndrome differentiation classification;
Fu Zi Li Zhong Tang;
Comparative effectiveness research
- From:
International Journal of Traditional Chinese Medicine
2016;38(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo assess the effect of Fuzi-Lizhongdecoction for the diarrhea irritable bowel syndrome (IBS-D) with the Chinese pattern of spleen kidney yang deficiency.MethodsA total of 98 patients diagnosed IBS-D with spleen kidney yang deficiency Chinese patternwere included from April,2014 toMarch, 2015 in our hospital,and were randomly divided into the control group and Traditional Chinese Medicine (TCM) group at ratio of 1:1, 9 paitents in each group, two groups were administrated with the convetional treatment such as correct water, electrolyte disorders. Besides, the control group was added withsulfasalazine treatment, and TCM group withFuzi-Lizhongdecoction. Outcomes includedchanges of symptoms scores, questionnaire scores, TCM syndrome scores, endoscopic scoresand adverse events.Results After treatment, the TCM group showed significantly lower scores of symptoms (1.80 ± 0.19vs. 490 ± 2.24,t=9.653), questionnaire (14.01 ± 7.11vs.31.44 ± 12.91,t=8.278), TCM syndrome (2.33 ± 0.10 vs.4.86 ± 0.93,t=18.934), endoscopic assessment (0.89 ± 0.03 vs.1.60 ± 1.14, t=4.358) than those of the control group (P<0.01). The TCM group showed significantly higher effective rate (93.88%vs.75.51%) than the control groupa (χ2=6.376,P=0.012). The adverse events of TCM group and control group were 0% (0/49) and 12.24% (6/49), and the difference was statistically significant (χ2=6.391,P=0.012).Conclusion Fuzi-Lizhong decoction is safe and effective therapy for IBS-D with Chinese pattern of Yang deficiency of spleen and kidney.
