Significance of HIF-1α, MVD and EGFR expression in detection of nasal inverted papilloma and clinical effect of taxol
10.3969/j.issn.1000-484X.2015.12.021
- VernacularTitle:HIF-1α、MVD及EGFR表达对鼻内翻性乳头状瘤恶变的诊断意义及紫杉醇干预效果分析
- Author:
Hao YANG
;
Yang ZHANG
;
Fang FAN
;
Wei Lü
;
Tianquan YANG
- Publication Type:Journal Article
- Keywords:
Nasal inverted papilloma;
Epidermal growth factor receptor;
Hypoxia inducible factor-1α;
Taxol;
Atypical hyper-plasia
- From:
Chinese Journal of Immunology
2015;31(12):1683-1687
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the significance of the expression of HIF-1α,MVD and EGFR on diagnostic of nasal inverted papilloma and the clinical effect of taxol .Methods:The expression of HIF-1α,MVD and EGFR were detected by immunohistochemistry in nasal inverted papilloma .Results:The expression of HIF-1α,MVD and EGFR were enhanced with the degree of atypical hyperplasia in epithelium.The research also showed that the expression of HIF-1α,MVD and EGFR were increased dramatically in severe atypical hyperplasia with a significant statistical differences ( P<0.01 ) .The expression of EGFR and MVD showed a positive correlation with HIF-1α.The administration of Taxol alleviated the enhanced expression of HIF-1α, MVD and EGFR with a significant statistical difference(P<0.01),but with on statistical difference with moderately severe tissue (P>0.05).Conclusion:HIF-1α,MVD and EGFR are involved in the pathogenesis and deteriorate of nasal inverted papilloma and can be taken as biomarkers for the diagnosis of the dete -rioration of nasal inverted papilloma .
