Clinicopathologic features of IgG4-related pulmonary inflammatory pseudo-tumor and its correlations with CD4+T lymphocytes and interleukin-10 expres-sion
10.3969/j.issn.1000-484X.2015.12.025
- VernacularTitle:IgG4相关肺炎性假瘤临床病理学特征及与CD4+T细胞和白介素10的关系分析
- Author:
Yudian HUANG
;
Yunshan TAN
;
Yuan JI
;
Haiying ZENG
- Publication Type:Journal Article
- Keywords:
IgG4;
Pulmonary inflammatory pseudotumor;
CD4+T lymphocyte;
Interleukin-10
- From:
Chinese Journal of Immunology
2015;31(12):1699-1703
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic features of IgG4-related pulmonary inflammatory pseudotumor (IRPIP), and its correlations with CD4+T lymphocytes and interleukin-10 (IL-10) expression,and to investigate the immunopathological factors in the disease of IgG4-related pulmonary inflammatory pseudotumor .Methods: Expressions of IL-10, CD3, CD20, CD4, CD8 were examined by immunohistochemistry in 17 cases of IgG4-related pulmonary inflammatory pseudotumor tissues and 15 cases of IgG4-nonrelated pulmonary inflammatory pseudotumor tissues ( INPIP) .To analyze the differences of these indexes expression between IRPIP and INPIP.Results: In group of IRPIP, the CD4+T lymphocytes number and the ratio of CD 4+T lymphocytes number/CD8+T lymphocytes number were all apparently higher than those in the group of INPIP (P=0.006,0.023,respectively).The cells numbers of CD3,CD8,IL-10 positive expression in IRPIP were higer than those in INPIP ,and the cells number of CD20 positive expression in IRPIP was lower than that in INPIP,but these differences all had no statistical significance (P>0.05).In IRPIP,the number of IgG4+plasmacytes was positively related to the number of IL-10+cell (r=0.517),the correlation had statistical significance (P=0.033). Conclusion:The number of CD4+T lymphocytes increased in addition to the increased number of IgG 4+plasmacytes in the lesion back-ground of IRPIP,and the number of IgG4+plasmacytes was positively related to the number of IL-10+cells.It is suggested that the increased number of Th 2 lymphocyte and the increased secretion of cytokine IL-10were are immunopathological factors participated in the disease of IRPIP .
