Research Strategy of New Chinese Medicine Based on Four Properties of Traditional Chinese Medicine
10.11842/wst.2015.11.003
- VernacularTitle:基于中药四性的中药新药研究策略
- Author:
Houwei WANG
;
Lin QIN
;
Jingzhen TIAN
;
Zhenguo WANG
- Publication Type:Journal Article
- Keywords:
Four properties of traditional Chinese medicine;
TCM model of standard level property;
active partial composition;
new drug research and development
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(11):2197-2201
- CountryChina
- Language:Chinese
-
Abstract:
The four properties theory of traditional Chinese medicine (TCM) is an important basis for the guidance of TCM clinical medication.However,TCM modernization has produced a large number of active substances with unknown medicine properties.Therefore,it is urgent to build a new drug development system guided with TCM four properties theory.From the view of that four properties of TCM must have their material basis,and based on the known knowledge on TCM four properties,this paper proposed strategies of new drug research by cloning TCM partial components based on theTCM model of standard level property. A certain number of representative standard level property TCM drugs were selected to conduct system separation for the establishment of aTCM model of standard level property with the proportion and content of each separated component as a reference.The standard model was used as a boundary.Contents and proportions of the experimental TCM separation components deviated from thisstandard model were classified as hot or cold properties.From cloning of the partial components of TCM with hot or cold property medicine,the quality standards of partial components of experimental TCM were also studied,in order to investigate their corrective actions and mechanisms.The TCM partial components were expected to form a new TCM drug with the four properties theory of TCM as guidance.
