Protective effects of Trimetazidine on ischemia-reperfusion injury of fatty liver in rats
10.11958/j.issn.0253-9896.2015.12.010
- VernacularTitle:曲美他嗪降低大鼠脂肪肝缺血再灌注损伤的研究
- Author:
Tengfei WANG
;
Tao YANG
;
Wei ZHANG
;
Zhenyu FANG
;
Honghai WANG
;
Lei LIU
;
Haiming ZHANG
;
Yuliang WANG
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
fatty liver;
reperfusion injury;
apoptosis;
bcl-2-associated X protein;
alanine transaminase;
aspartate aminotransferases;
malondialdehyde;
superoxide dismutase;
caspase-3
- From:
Tianjin Medical Journal
2015;(12):1382-1385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of Trimetazidine(TMZ)on the ischemia reperfusion injury (IRI)of fatty liver in autotransplantation model. Methods Fatty liver model was established by feeding high fat diet. Male Wistar rats (n=30) were randomized into three groups;Sham group, TMZ group and Model group. Liver was autotransplanted in both TMZ group and Model group. Serum levels of ALT, SOD, MDA, Bcl-2 and activated Caspase-3 were assessed 6 hours after the operation. The pathological performances of liver were also determined. Results Compared with the Model group, serum levels of ALT,AST, MDA and SOD levels decreased significantly in the TMZ group(P<0.05). Serum level of Bcl-2 was higher while level of activated Caspase-3 was lower in TMZ group than those in Model group(P<0.05). Histo?logical assay and TUNEL staining showed reduced hepatocyte swelling and narrowed sinusoid as well as decreased hepatic apoptosis in TMZ group compared with Model group. Conclusion TMZ can reduce oxidative stress, promote the expression of Bcl-2 and inhibit the activation of Caspase-3, which all contribute to its protective effect on fatty liver with ischemia-re?perfusion injury.
