Effects of nicorandil on cardiac function and clinical outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention
10.3969/j.issn.1006-5725.2016.04.011
- VernacularTitle:尼可地尔对急性心肌梗死患者冠状动脉介入术后心功能及临床预后的影响
- Author:
Zhengxin HUANG
;
Xianbao WANG
;
Yingfeng LIU
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Nicorandil;
Reactive oxygen species;
Cardiac function;
Clinical outcomes
- From:
The Journal of Practical Medicine
2016;32(4):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of nicorandil on cardiac function and clinical outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Method Sixty-six patients with AMI were randomized into a control group and nicorandil group (n = 33 for each group). In the nicorandil group, nicorandil (4 mg as a bolus injection followed by constant infusion at 8 mg/hour for 24 hours) was administered immediately after admission. Reactive oxygen species (ROS) formation was assessed by measuring urinary excretion of 8-epi-prostaglandin F2α (PGF2α) and compared between the two groups; cardiac function and cardiac events were also compared. Results Urinary 8-epi-PGF2αexcretion was increased 2-fold at 60 to 90 minutes after PCI in the control group, whereas it was unchanged in the nicorandil group (P < 0.001). Left ventricular ejection fraction and cardiac index immediately after PCI and at 6 months were greater in the nicorandil group than in the control group(P < 0.05). Rates of total inhospital cardiac events and rehospitalization were lower in the nicorandil group than in the control group (P<0.05). Conclusions Nicorandil improves cardiac function and clinical outcomes in patients with AMI undergoing primary percutaneous coronary intervention. Suppression of ROS formation may be involved in the potential mechanism.
