Efficacies of rhGH alone and rhGH combined with stanozolol therapies on growth velocity of girls with Turner syndrome
10.3969/j.issn.1006-5725.2016.04.015
- VernacularTitle:单用rhGH与rhGH联合小剂量司坦唑醇对改善Turner综合征患者生长速度的比较
- Author:
Dan LI
;
Hongshan CHEN
;
Minlian DU
;
Yanhong LI
;
Huamei MA
;
Qiuli CHEN
;
Jun ZHANG
;
Yufen GU
- Publication Type:Journal Article
- Keywords:
Turner syndrome;
Recombinant human growth hormone;
Growth velocity;
Stanozololgrowth
- From:
The Journal of Practical Medicine
2016;32(4):559-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the different efficacies of recombinant human growth hormone (rhGH) alone and rhGH combined with low-does stanozolol on growth velocity (GV) of girls with Turner syndrome (TS). Methods 51 girls with TS were divided into two groups: Group 1 (n = 23) were treated with rhGH alone and group 2 (n = 28) with rhGH combined with low-does stanozolol both for more than six months. The two groups were compared in terms of GV, height standard deviation score for chronologic age (HtSDSCA), HtSDS for bone age (HtSDSBA), HtSDS (ΔHtSDS) and the ratio of ΔBA/ΔCA. Results In the first year, the GV was (6.29 ± 1.44) and (8.13 ± 1.87) cm/a in Group 1 and Group 2, respectively. HtSDSCA changed from (-3.51 ± 0.99) to (-3.19 ± 1.09) and (-4.21 ± 1.19) to (-3.43 ± 1.06), and ΔBA/ΔCA was (0.60 ± 0.39) and (0.77 ± 0.56) in Group 1 and Group 2, respectively. The GV and ΔHtSDS in Group 2 were significantly better than Group 1 (P < 0.05). The GV was negatively correlated with the age. Conclusion Compared with the therapy with rhGH alone, the one with rhGH combined with low-dose stanazolol is more effective in improving GV without accelerating bone maturation among the girls with Turner syndrome.
