Current research in roles of CD38,CD138 and IgG4 in the pathogenesis of biliary atresia
10.11958/j.issn.0253-9896.2015.12.031
- VernacularTitle:CD38、CD138、IgG4在胆道闭锁发病中作用的研究进展
- Author:
Ting GAO
;
Jianghua ZHAN
- Publication Type:Journal Article
- Keywords:
biliary atresia;
antigens,CD38;
syndecan-1;
immunoglobulin G;
hepatitis,autoimmune;
CD138;
IgG4
- From:
Tianjin Medical Journal
2015;(12):1460-1463
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia (BA) is one of the most serious pediatric surgical digestive system diseases with progressive liv?er bile duct inflammation and fibrous obstruction. Currently, the etiology of BA is not clear. It may be associated with genetic predisposition, viral infections and immune injury. Now many scholars believe that it was resulted from multiple factors. Among them, the theory of immune-inflammatory is supported by most scholars. Now the mechanisms of CD38, CD138 and IgG4 in autoimmune liver disease were reported in literature. BA and other autoimmune liver diseases are similar in terms that both inflammatory and immune responses plays irreplaceable role during disease development. Therefore, this article briefly review the role of CD38, CD138 and IgG4 in the inflammation-immunity of BA.
