The relationship between Prdx1 and carcinoma
10.11958/j.issn.0253-9896.2015.12.032
- VernacularTitle:Prdx1与肿瘤
- Author:
Jun GAO
;
Hong ZHU
;
Guolan GAO
- Publication Type:Journal Article
- Keywords:
Prdx1;
peroxidase;
neoplasms
- From:
Tianjin Medical Journal
2015;(12):1464-1466
- CountryChina
- Language:Chinese
-
Abstract:
Peroxiredoxin 1(Prdx1)belongs to peroxide oxidoreductase protein(peroxiredoxin, Prdx)family,which is over-expressed in multiple cancers and it play an important role in antagonizing reactive oxygen species (ROS) therefore as works as anti-oxidations. Its expression is closely related with tumor proliferation, differentiation and metastasis as well as with sensibility to radiotherapy and chemotherapy. Its structure and biological function in tumors and regulation mechanism were reviewed in this paper. It can provide evidence to screen new therapeutic targets in the treatment of tumors.
