Current research of the role of Sox2 in Glioblastoma Multiforme
10.11958/j.issn.0253-9896.2015.12.033
- VernacularTitle:Sox2在胶质母细胞瘤中的研究进展
- Author:
Jinman GUO
;
Chao TAN
;
Huojun HU
;
Yuan TAN
- Publication Type:Journal Article
- Keywords:
glioblastoma;
central nervous system neoplasms;
gene therapy;
review;
Sox2
- From:
Tianjin Medical Journal
2015;(12):1467-1469
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma (GBM) is one of the WHO gradeⅣmalignancies, which is an acentral nervous system cancer with poor prognosis unless the lesion is in the brain stem. The incidence of GBM accounts for 80%of human primary malignant tumors in brain. Only 5%GBM can survive up to 5-years. Many researches showed that Sox2 is a pluripotent regulator, and muta?tion or abnormal function of Sox2 are closely related to the development of GBM. There are studies demonstrated the possibil?ity of using Sox2 gene as apotential target for GBM therapy. This paper reviewed recent progress in GBM.
