Optimization of Compatibility Conditions of Erigeron Injection by Orthogonal Test and Study on the Stabil-ity of Compatibility Solution
- VernacularTitle:正交试验法优选灯盏细辛注射液配伍条件及配伍液的稳定性考察
- Author:
Huixian SHEN
;
Zhihui ZHAO
;
Guirong WANG
- Publication Type:Journal Article
- Keywords:
Orthogonal test;
Erigeron injection;
Compatibility condition;
Stability
- From:
China Pharmacist
2015;18(12):2187-2189
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the compatibility conditions of erigeron injection and study the stability after compatibility. Methods:An orthogonal test was employed using the quantity of insoluble particles and the content of rutin as the indices and tempera-ture, solvent and solvent amount as the influencing factors. The results were comprehensively analyzed. According to the results of the orthogonal test, three batches of samples were prepared and observed the stability in 24 hours, including the changes in the number of insoluble particles, pH and total flavonoid content. Results:The optimal compatibility conditions were as follows:the temperature was 25℃, and 250 ml 0. 9% sodium chloride injection was used as the solvent. The appearance and the insoluble particles showed no sig-nificant changes in 24 hours. The total flavonoid content was also stable in 4 hours, but decreased to some extent after then. Conclu-sion:At the clinical dose, erigeron injection in 250 ml 0. 9% sodium chloride injection can keep stable in 4 hours.
