Expressions of HBXIP and GRIM-19 in hepatocellular carcinoma and their clinic significance
10.11958/j.issn.0253-9896.2015.12.006
- VernacularTitle:肝细胞癌组织HBXIP和GRIM-19表达及意义的探讨
- Author:
Jisan SUN
;
Jianjun ZHANG
;
Wei GAO
;
Tao YANG
;
Qingjun GUO
;
Nan MA
;
Honghai WANG
;
Wentao JIANG
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
neoplasm metastasis;
immunohistochemistry;
HBXIP;
GRIM-19
- From:
Tianjin Medical Journal
2015;(12):1364-1367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of HBXIP and GRIM-19 in hepatocellular carcinoma tissues and their clinic significance. Methods Hepatocellular carcinoma tissue (n=42) and normal liver tissue (n=28) were collected from Tianjin First Central Hospital,immunohistochemistry was used to detect the expressions of HBXIP and GRIM-19 in these two groups. Results Rate of cells with positive expressions of HBXIP in hepatocellular carcinoma and normal liver tissues were 80.95%(34/42)and 42.86%(12/28)respectively;Rate of cells with positive expression of GRIM-19 in hepato?cellular carcinoma tissues and normal liver tissues was 40.48%(17/42)and 75.00%(21/28)respectively, and the difference between these two groups was statistically significant(P<0.05);The expression of HBXIP was higher but the expression of GRIM-19 was lower in poor differentiated and stageⅢ-IV cells than those in well and moderate differentiated cells and in stage I-II, cells. What′s more, the expression of GRIM-19 is higher in tissue without portal thrombosis than that in tissue with portal thrombosis. The expression of HBXIP was negatively correlated with GRIM-19 expression(rS=-0.400,P<0.01). Conclusion The abnormal expressions of HBXIP and GRIM-19 may play important roles in the process of development and metastasis of hepatocellular carcinoma.
