Observation on clinical effects of three different treatment regimens for conservative treatment of ectopic pregnancy
10.3969/j.issn.1673-4130.2015.23.032
- VernacularTitle:三种不同药物方案保守治疗异位妊娠的疗效观察
- Author:
Xiaosong LI
;
Yanli HU
;
Xiaorong LIU
;
Yong QIN
- Publication Type:Journal Article
- Keywords:
ectopic pregnancy;
conservative treatment;
methotrexate;
mifepristone
- From:
International Journal of Laboratory Medicine
2015;(23):3439-3441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic efficacy of three different treatment regimens for conservative treatment of ec‐topic pregnancy(EP) .Methods Clinical data of 198 cases of patients with EP who were conservatively treated in this hospital from June 2012 to June 2014 were retrospectively analysed .All patients were divided into group A (39 cases) ,group B(92 cases) and group C(67 cases) ,which were treated with single‐dose of methotrexate(MTX) ,MTX combined with mifepristone and multiple‐dose of MTX respectively .The curative rate and time for human chorionic gonadotropin beta‐subunit(β‐HCG) dropping to normal were observed and recorded .Results The total curative rates in three groups were statistically different (P<0 .05) ,additionally , group C had the highest curative rate(86 .57% ) ,followed by group B with 84 .78% and group A with 66 .67% .In the three groups , for patients with serum level of β‐HCG 1 500-3 000 mIU/mL or >3 000 mIU/mL ,the curative rates were statistically different (P<0 .05) .Conclusion Single‐dose of MTX has relative low curative rate .It is recommend to use combination regimens or multi‐ple‐dose of MTX regimens ,and for patients with high level of β‐HCG multiple‐dose of MTX regimens might be the best choice .
