The diagnostic value of combined detection of four indexes in early diagnosis of nephropathy
10.3969/j.issn.1673-4130.2015.23.017
- VernacularTitle:4项指标联合检测在肾脏疾病早期诊断中的意义
- Author:
Juanjuan HU
;
Tiecheng ZHOU
;
Kai TONG
;
Xiaoyan LI
;
Xiaodong CHENG
- Publication Type:Journal Article
- Keywords:
cystatin C;
retinol-binding protein;
urea nitrogen;
creatinine;
joint detection
- From:
International Journal of Laboratory Medicine
2015;(23):3405-3406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of joint detection of serum cystatin C (Cys C) ,retinol‐binding protein(RBP) ,urea ni‐trogen(BUN) and creatinine(Cr) in early diagnosis of nephropathy .Methods A total of 230 cases of inpatients with nephropathy form April 2013 to June 2014 were collected and divided into diabetic nephropathy group (130 cases)and hypertensive nephropathy group(100 cases) .Other 200 healthy individuals were collected as healthy control group .The serum levels of Cys C ,RBP ,BUN and Cr were detected by using the Hitachi 7180 automatic biochemistry analyzer .Results Compared with the healthy control group ,the sertum levels of Cys C ,RBP ,BUN and Cr were significantly increased in the diabetic nephropathy group ,and the serum levels of Cys C and RBP were significantly increased in hypertensive nephropathy group ,there were statistically significant differences (P<0 .05);while no statistically significant differences in serum levels of BUN and Cr were found between the hypertensive nephropathy group and healthy control group(P>0 .05) .Positive rates(81 .9% ) of the four indicators in the two nephropathy groups were high‐er than those in the healthy control group ,and the positive rate of joint detection of the four indicators was higher than single detec‐tion in patients with nephropathy .Conclusion Serum RBP and Cys C are sensitive indicators for early renal damage ,and combined with BUN and Cr could increase sensitivity of early diagnosis of nephropathy ,which has significant clinical value .
