Application of the glycogen phosphorylase BB and heart-type fatty acid binding protein to the early diagnosis of neonatal myocardial injury
10.3969/j.issn.1006-5725.2015.22.025
- VernacularTitle:糖原磷酸化酶同功酶脑型及心脏型脂肪酸结合蛋白在新生儿心肌损害中的应用
- Author:
Jihong WEI
;
Jinxiu BAI
;
Xiaowei YANG
;
Boyu WANG
;
Lei ZHANG
;
Ronglin YU
;
Xiuwen ZHAO
- Publication Type:Journal Article
- Keywords:
Myocardial injury;
Glycogen phosphorylase BB;
Heart-type fatty acid binding protein;
Infant;
Newborn
- From:
The Journal of Practical Medicine
2015;31(22):3711-3713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficiency of glycogen phosphorylase BB (GPBB) and heart-type fatty acid binding protein (H-FABP) in the early diagnosis of neonatal myocardial injury (NMI). Methods The GPBB and H-FABP levels in the blood were detected at 3, 6, 12 and 24 h after onset of the NMI. The GPBB and H-FABP levels were compared among NMI, Non-NMI and control groups. The NMI diagnosis sensitivity and specificity for GPBB, H-FABP, GPBB combined with H-FABP were compared. The relationships of GPBB, H-FABP levels with the risk factors were analyzed. Results The GPBB and H-FABP levels of NMI group were higher than those of Non-NMI and control groups (P < 0.01). The diagnosis sensitivity of four time points (3, 6, 12 and 24 h) of combined GPBB and H-FABP were higher than those of the GPBB and H-FABP (P < 0.05). The GPBB and H-FABP were negatively correlated with blood glucose level, positively correlated with asphyxia degree and septicemia degree. Conclusion The combined application of GPBB and H-FABP can improve sensitivity in the early diagnosis of NMI.
