Study on Compatibility Stability of Alanylglutamine by Using Continuous Series Infusion Device
10.3870/j.issn.1004-0781.2015.12.028
- VernacularTitle:串联混合输注装置中丙氨酰谷氨酰胺配伍稳定性考察
- Author:
Chengliang ZHANG
;
Chengyang FENG
;
Yanjiao XU
;
Zaoqin YU
;
Dong LIU
- Publication Type:Journal Article
- Keywords:
Alanylglutamine;
Continuous series infusion device;
Stability;
compatible
- From:
Herald of Medicine
2015;34(12):1657-1659
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the compatible stability of alanylglutamine by using continuous series infusion device,and provide experimental evidence for reasonable clinical use of alanylglutamine. Methods pH,osmolality and quantity of insoluble particles were measured by using pH meter, automatic freezing osmometer and intelligent particle detector respectively.A HPLC method was built for the determination of the content of alanylglutamine. Results pH and quantity of insoluble particles of the two tested groups did not change significantly over time. Osmolality and the content of alanylglutamine fluctuated greatly in the first half an hour. Conclusion Continuous series infusion device may not mix each bottle of solution very well.It is suggested to premix these solutions to ensure the stability of the dilution ratio and the osmotic pressure of the mixture in the process of the infusion.
