The efficacy of platelet-rich plasma and hyaluronic acid intra-articular injection in the treatment of knee osteoarthritis: a meta-analysis
10.3969/j.issn.1006-5725.2015.22.045
- VernacularTitle:富血小板血浆与透明质酸治疗膝骨关节炎疗效的Meta分析
- Author:
Chengbao ZHANG
;
Xinlong MA
;
Jianxiong MA
;
Ying WANG
;
Chen WANG
;
Xuan JIANG
;
Lei SUN
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
Knee;
Platelet-rich plasma;
Hyaluronic acid;
Meta-analysis
- From:
The Journal of Practical Medicine
2015;31(22):3772-3774
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of platelet-rich plasma and hyaluronic acid intra-articular injection in patients with knee osteoarthritis. Method The following databases, including PubMed, Embase, the Cochrane Library and WANFANG, were used for collecting the randomized controlled trials, prospective control trials and experimental research about the therapy efficacies of platelet-rich plasma and hyaluronic acid on knee osteoarthritis. The meta-analysis was performed using RevMan 5.3 for Windows. Results Eleven publications, including six RCTs, one PCT and four ER, met the inclusion criteria. There were significant differences in WOMAC scores and IKDC scores between the PRP group and the HA group. but no significant differences were observed in Lequesne index between the PRP group and the HA groups at six month post treatment. Conclusion PRP intra-articular injection was better and more durable than HA in the treatment of knee osteoarthritis.
