Formulation Screening and Determination of Troxerutin Microemulsion
10.3870/j.issn.1004-0781.2015.12.020
- VernacularTitle:曲克芦丁微乳的处方筛选及含量测定
- Author:
Man XU
;
Qing YU
;
Qianru ZHAO
;
Wei CHEN
;
Yuanjie LIN
;
Yong JIN
- Publication Type:Journal Article
- Keywords:
Troxerutin;
Pseudoternary phase diagram;
Microemulsion;
Quality evaluation
- From:
Herald of Medicine
2015;34(12):1627-1632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize a W/O microemulsion formulation of troxerutin and evaluate its physical properties such as morphology, droplet size, stability and content of troxerutin. Methods The W/O microemulsion was optimized using a pseudoternary phase diagram and the area of the microemulsion region was used to screen and determine microemulsion components.HPLC assay was used for determination of the loading content. Results The optimal formulation contained lecithin, ethanol, isopropyl myristate and water (23.30:11.67:52.45:12.59).The microemulsion was physicochemically stable with round shape and uniform size, and the mean droplet size was about 50. 20 nm. Conclusion Microemulsion was developed successfully.It will expect to be the new preparation for troxerutin.
