Research progress of chronic intermittent hypoxia animal models
10.3969/j.issn.1001-1978.2016.04.001
- VernacularTitle:慢性间歇性低氧动物模型的比较
- Author:
Linqin MA
;
Jingchun ZHANG
;
Yue LIU
- Publication Type:Journal Article
- Keywords:
animal models;
chronic intermittent hypoxia (CIH);
obstructive sleep apnea hypopnea syndrome(OSAHS);
cardiovascular diseases;
hypertension;
atherosclerosis( AS)
- From:
Chinese Pharmacological Bulletin
2016;32(4):445-450
- CountryChina
- Language:Chinese
-
Abstract:
Chronic intermittent hypoxia ( CIH ) caused by ob-structive sleep apnea hypopnea syndrome( OSAHS) is an impor-tant factor causing or aggravating many kinds of cardiovascular and cerebrovascular diseases. Establishing a rational animal model for intermittent hypoxia is an essential method to study the CIH related cardiovascular diseases. Recently, researchers have tended to simulate intermittent hypoxia condition by controlling the oxygen concentration of the environmental air around the ani-mals. In the paper, we summarize and compare the methods of making intermittent hypoxia animal model in recent literature, from aspects of experimental animals, gas control apparatus, gas species and concentration, intermittent hypoxia treatment time, and anoxic cycle mode.
