Animal models of alcohol liver diseases
10.3969/j.issn.1001-1978.2016.04.006
- VernacularTitle:酒精性肝病动物模型研究进展
- Author:
Heng ZHOU
;
Jun LI
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
alcoholic liver diseases;
animal models;
fatty liver;
liver injury;
inflammation;
fibrosis
- From:
Chinese Pharmacological Bulletin
2016;32(4):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Chronic alcohol consumption is a leading cause of chronic liver diseases worldwide, resulting in cirrhosis and hepa-tocellular carcinoma. Almost all heavy drinkers develop fatty liv-er, but only 20% ~40% of them develop more severe forms of alcoholic liver diseases such as alcoholic hepatitis and alcoholic fibrosis, and the underlying mechanisms that contribute to the disease progression remain largely unknown. The animal models which can mimic human alcoholic liver diseases are very neces-sary tools for better understanding and exploring the therapy strat-egy of the disease. Currently, the most widely used models for alcoholic liver injury are Lieber-DeCarli model, Tsukamoto-French model, Gao-binge model and others. Here we summarize the recent advances in animal models recapitulating different fea-tures and etiologies of human alcoholic liver diseases. These ani-mal models will be very useful for the mechanism study of alco-holic liver diseases and further new therapeutic drug screening.
