The feasibility investigation of experimental animal model of cerebral alveolar echinococcosis disease of sheep
10.3969/j.issn.1002-1671.2016.03.032
- VernacularTitle:羊脑泡状棘球蚴病实验模型建立可行性探讨
- Author:
Weihong YAO
;
Quan ZHANG
;
Jian WANG
;
Tao JIANG
;
Chunhui JIANG
;
Deqing ZHANG
;
Juan MA
;
Ling WU
- Publication Type:Journal Article
- Keywords:
cerebral alveolar echinococcosis disease;
Xinjiang sheep;
animal model;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2016;32(3):448-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To build experimental animal model of cerebral alveolar echinococcosis disease of sheep,in order to study of human alveolar hydatid disease of the brain.Methods Experiment animal models of ten Xinjiang big-tail sheep were performed by, direct skull puncture,intracerebral inoculation of echinococcus multilocularis.MRI was used to observe the growth status of cerebral alveolar echinococcosis disease of sheep after 8 months,and morphological and pathological characteristics after autopsy were ana-lysed.Results 4 sheep models (40%)were successful built which were confirmed by pathology and MRI.On MRI,4 cases all were single lesion,on T2 WI there was multiple follicles bubbles under the background of low signal in one case,and low signal in other three cases.Under the microscope,a large number of lymphocytes,eosinophils and plasma cells infiltrated the lesion area,around which small blood vessels were blocked and had inflammatory reaction were showed.Conclusion The method using artificial inocula-tion rat alveolar echinococcosis to establish experimental model of cerebral alveolar echinococcosis disease of sheep has the character-istic of feasibility,simplicity and repeatability.
