Association of MYH9,STAT4 and uPA gene single nucleotide polymorphism with idiopathic membranous nephropathy
10.3969/j.issn.1006-5725.2016.03.010
- VernacularTitle:MYH9、STAT4、uPA 基因多态性与特发性膜性肾病的相关性
- Author:
Yu GUO
;
Lu LI
;
Kaihong GU
;
Zongfeng ZHAO
;
Dan XU
;
Chen LU
- Publication Type:Journal Article
- Keywords:
Idiopathic membranous nephropathy;
Signal transducer and activator of transcription;
Nonmusle myosin heavy chain 9 gene;
Urokinase plasminogen activator;
Single nucleotide polymorphism
- From:
The Journal of Practical Medicine
2016;32(3):376-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate thecorrelation between nonmusle myosin heavy chain 9 gene (MYH9) rs12107,signal transducer and activator of transcription (STAT4) rs3024912, Urokinase plasminogen activator (uPA) rs4065 single nucleotide polymorphism and idiopathic Uighur membranous nephropathy (IMN). Methods Patients admittedby People′s Hospital of Xinjiang Uyghur Autonomous Region from June 2011 to May 2015 were selected in the research,of which 45 with IMN (group A),45 patients with IgA nephropathy (group B) and 45 healthy controls(group C). The polymorphisms of rs12107,rs3024912 and rs4065 were measured with direct sequencing, in order to analyzing the correlation between genotype and allele with IMN. Results Group Ars12107 (MYH9) locus genotype CC, C allele (48.9%, 65.6%) frequency were higher than those in group B (13.3%, 33.3%) and group C (20.0%, 46.7%), and the difference was statistically significance (P < 0.05). C allele carriers of the risk of IMN is 2.18 times that of the T allele (95% CI: 1.19-3.97). Univariate Logistic regression analysis of rs12107 CC genotype showed patients with CC genotype faced with high risk of renal failure (OR = 5.56,95% CI:1.27-24.29, P = 0.023) compared with non-CC genotype patients. rs3024912 genotype and allele frequencies showed no significant difference among the three groups (P > 0.05). rs3024912 GG genotype patients showed higher risk of renal failure compared with non-GG genotype patients (95% CI:1.48-26.83, P = 0.013). Only TT genotype was detected on rs4065 locus. TC and CC genotype were not detected. Conclusions MYH9 gene rs12107 locus CC genotype and C allele are associated with susceptibility to IMN in Xinjiang Uygur, and CC genotypes associated with renal function. rs3024912 (STAT4)GG genotype are not susceptibility gene,but associated with renal function in patients with IMN.
