The primary clinic application of hyperthermic intraperitoneal chemotherapy (HIPEC) guided by B ultrasound in the treatment of malignant ascites
10.3969/j.issn.1006-5725.2016.03.029
- VernacularTitle:B超引导下持续循环腹腔热灌注化疗治疗恶性腹水的临床应用初探
- Author:
Yinbing WU
;
Mingxin PAN
;
Shuzhong CUI
;
Mingchen BA
;
Zulong CHEN
;
Qiang RUAN
- Publication Type:Journal Article
- Keywords:
Hyperthermic intraperitoneal infusion;
Ultrasonography;
Chemotherapy;
Malignant ascites;
Peritoneal arcinomatosis
- From:
The Journal of Practical Medicine
2016;32(3):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the measurement , feasibility and clinic effect of hyperthermic intraperitoneal chemotherapy (HIPEC) guided by B ultrasound in the treatment of malignant ascites from peritoneal carcinomatosis. Methods From July 2011 to June 2013, B ultrasound-guided approach was used to perform HIPEC on 36 patients affected by malignant ascites secondary to peritoneal carcinomatosis. Every patient underwent HIPEC for three times , by way of continuous circulatory perfusion into peritoneal cavity with saline at 400 ~ 600 mL/min and intraperitoneal perfusion with 5-FU mitomycin-C and cisplatin for 90 minutes with an inflow temperature of (43 ± 0.2)℃. These patients were followed up for a long term. Results Intraoperative course was uneventful in all cases. Complete clinical regression of ascites and related symptoms was achieved in all the 26 patients, partial regression achieved in 8 patients, and no curative effect achieved in 2 cases. The acquired total clinic effectiveness was 94.44%. No postoperative deaths and complication related to the procedure occurred in this study. The KPS grades of patients rose (P < 0.001), the level of tumor markers decreased, including CA199 (P < 0.001), CEA (P < 0.001), CA125 (P = 0.003). Conclusion HIPEC guided by B ultrasound appears to be a safe, feasible and effective procedure for the treatment of debilitating malignant ascites from unresectable peritoneal carcinomatosis , which would have a clinic good perspective in future.
