Expression of CTLA-4 in T lymphocytes of patients with glioma and its clinical significance
10.13481/j.1671-587x.20160223
- VernacularTitle:胶质瘤患者T淋巴细胞表面CTLA-4的表达及其临床意义
- Author:
Ruitai FAN
;
Heng ZHANG
;
Xin WANG
;
Hao GU
- Publication Type:Journal Article
- Keywords:
glioma;
T-lymphocyte;
cytotoxic T-lymphocyte associated antigen-4
- From:
Journal of Jilin University(Medicine Edition)
2016;42(2):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the CTLA-4 expression in the peripheral blood CD4+ and CD8+T cells in the patients with glioma and glioma WHO classification and operation,and to clarify the clinical significances of CTLA-4.Methods:60 patients with glioma from our hospital were selected as glioma group, and 46 healthy volunteers were used as control group.Then the CTLA-4 expression levels in the peripheral blood CD4+ and CD8+T cells of the subj ects in glioma group and control group were detected by fluorescence-activated cell sorting (FACS)and the relationship between CTLA-4 and glioma WHO classification and surgery was analyzed. Results:The CTLA-4 expression levels in CD4+ and CD8+T cells in peripheral blood of the patients in glioma group were higher than those in control group (P<0.01).The CTLA-4 expression level in the patients with gradeⅣ glioma was the highest, the expression level of the patients with grade Ⅳ glioma was higher than that of the patients with grade Ⅲ glioma (P<0.01),and the expression level of grade Ⅲ the patients with was higher than that of the patients with grade Ⅱ (P<0.01).The expression level of CTLA 4 in CD4+ and CD8+T cells of the patients with glioma after operation was lower than before operation (P<0.01 ). Conclusion:The CTLA-4 expression levels in the peripheral blood CD4+ and CD8+T cells are increased with the increasing of malignancy degree of the patients with glioma,and it has a promotion role in the occurrence of development of glioma.
