Predictive Value of Inflammatory Factors on All Cause Mortality in Normal Population：6.9 Years Follow-up Results in Kailuan Group for 83,000 Subjects
10.3969/j.issn.1000-3614.2016.03.010
- VernacularTitle:炎症因子对全因死亡的预测价值研究：开滦集团8.3万职工6.9年随访结果
- Author:
Xin DU
;
Chunpeng JI
;
Ying ZHANG
;
Jihong SHI
;
Zhe HUANG
;
Chenrui ZHU
;
Huiying LI
;
Xiaoming WEI
;
Liming LIN
;
Hailiang XIONG
;
Yan LIU
;
Shouling WU
- Publication Type:Journal Article
- Keywords:
Leukocytes;
Neutrophils;
Lymphocytes;
C-reactive protein;
Cause of death
- From:
Chinese Circulation Journal
2016;31(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the predictive value of inlfammatory factors on all cause mortality in normal population.
Methods: In our prospective cohort study, a total of 83,228 subjects from physical examination of Kailuan group from 2006-07 to 2007-10 were enrolled, nobody had acute inlfammation. The death information was collected once per year and the last follow-up was conducted in 2013-12-31. According to baseline levels, white blood cells (WBC), ratio of neutrophil/lymphocyte ratio (N/L) and C-reactive protein (CRP) were respectively divided into 4 Quartile groups; all cause mortality was compared among different groups and their risks were studied by multi-Cox regression analysis.
Results: The average follow-up time was 6.9 years. All cause mortality in Quartile 1, Quartile 2, Quartile 3 and Quartile 4 groups for WBC were 4.2%, 4.5%, 4.5% and 5.0% respectively; for N/L were 3.3%, 3.6%, 4.5% and 6.7% respectively; for CRP were 3.0%, 3.6%, 4.8% and 6.8% respectively. Multi-Cox regression analysis indicated that with adjusted age, gender, waist and other confounders, by elevation of WBC, N/R and CRP, the risks of all cause mortality were increased accordingly, and the risks in Quartile 4 groups were higher than those in Quartile 1 groups as for WBC, it was 1.17-time (95% CI 1.06-1.29);for N/L, it was 1.44-time (95% CI 1.31-1.59); for CRP, it was 1.33-time (95% CI 1.20-1.47) respectively.
Conclusion: Elevated WBC, N/R and CRP are independent risk factors for all cause mortality in normal population.
