The protection effect and mechanism of aloe polysaccharide on experimental colitis mucosa
10.3969/j.issn.1006-5725.2016.03.004
- VernacularTitle:芦荟多糖对实验性结肠炎大鼠肠黏膜的保护作用及其机制研究
- Author:
Wenzhi ZHANG
;
Shuiping OU
;
Huichao WU
;
Qingsheng YU
- Publication Type:Journal Article
- Keywords:
Colitis;
Aloe polysaccharide;
IL-4;
IL-13;
IFN-γ;
IL-12
- From:
The Journal of Practical Medicine
2016;32(3):352-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of aloe polysaccharide on experimental colitis mucosal. Methods The TNBS-induced experimental rat colitis model was successfully established and were treated by aloe polysaccharide, and enteric-coated tablets with sulfasalazine (SASP). Results DAI score, gross morphology score , histopathologic score and MPO in the model group were significantly higher than that in the normal group (P < 0.01), while those indicators were significantly lower after treatment (P < 0.01), IL-12 and IFN-γ mRNA and protein expressions in the model group were significantly higher than that in the normal group (P < 0.01), and IL-12 and IFN-γ expression levels in treatment group were significantly lower than that in the model group (P < 0.01), IL-4 and IL-13 mRNA and protein expression levels in the model group were significantly lower than that in the normal group (P < 0.01), and IL-4 and IL-13 expression in treatment group was significantly higher than that in the model group (P < 0.01). Conclusion Aloe polysaccharide on experimental colitis in rats has a good protective effect , of which mechanism may be reduced by IFN-γ and IL-12 levels, increased IL-4, IL-13 levels, and correct the imbalance of Thl/Th2.
