Meta-analysis on curative effects of statins in treatment of pneumoniaor or sepsis
10.13481/j.1671-587x.20160228
- VernacularTitle:他汀类药物辅助治疗肺炎或脓毒症疗效的Meta分析
- Author:
Lijie QIU
;
Ye ZHANG
;
Wenjing ZHANG
;
Donghua QIAN
- Publication Type:Journal Article
- Keywords:
statins;
pneumonia;
sepsis;
Meta-analysis
- From:
Journal of Jilin University(Medicine Edition)
2016;42(2):336-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review the effects of statins in the treatment of the patients with pneumonia or sepsis, and to provide evidence-based basis for the using of statin in treatment of pneumonia or sepsis.Methods:PubMed, Embase, The Cochrane Library, CNKI, WanFang Data and VIP were searched for randomized placebo-controlled trials of statins published from the establishment time of datebases to January 31, 2015.The qualities of the included studies were independently assessed by two reviewers and the relevant data was extracted for analysis using Review Manager 5.3. Results:Nine trails involving a total of 1 227 patients were included.①A total of 6 studies about the mortality of hospitalized patients were included in the Meta-analysis;compared with placebo group, statins didn’t improve the mortality of hospitalized patients with pneumonia or sepsis;risk ratio (RR)= 0.83,95%CI (0.63,1.08),P=0.17.②A total of 7 studies about the rates of mechanical ventilation usage or ICU admission of the patients were included in the Meta-analysis. Compared with placebo group,statins didn’t improve the rates of mechanical ventilation usage or ICU admission of the patients with bacteria infection;RR= 0.99,95% CI (0.96,1.03),P=0.62.③A total of 4 studies about the levels of C reaction protein (CRP)were included in the Meta-analysis. Compared with placebo group, statins significantly reduced the levels of CRP;mean differences (MD)=-8.30 mg·L-1,95%CI (-12.13,-4.47),P<0.0001. Conclusion:Statins can not significantly reduce both the in-hospital mortality and the rates of mechanical ventilation usage or ICU admission, but can significantly reduce the plasma CRP levels, and reduce the inflammation.
