Alterated Serum Levels of Immunoglobulin E in Patients With Calcific Aortic Valve Disease

VernacularTitle:钙化性主动脉瓣疾病患者血清免疫球蛋白E水平的变化
Author: Yunyi ZHENG ; Qingchun ZENG ; Qiong ZHAN ; Dingji ZHU ; Jinghai HUA ; Haobin ZHOU ; Dongqi AN ; Zuheng LIU ; Wenyan LAI ; Dingli XU
Publication Type:Journal Article
Keywords: Heart valve diseases; Atherosclerosis; Immunoglobulin E; Mast cell; Inlfammation
From: Chinese Circulation Journal 2016;31(3):263-266
CountryChina
Language:Chinese
Abstract: Objective: To explore the relationship between serum levels of immunoglobulin E (IgE) and calciifc aortic valve disease (CAVD) in relevant patients.
Methods: A total of 394 patients were enrolled in our study. Based on echocardiography presentation, the patients were divided into 2 groups: CAVD group,n=169 and Non-CAVD group,n=225. Serum levels of IgE were examined by chemiluminescence method. The IgE levels were compared between 2 groups and the relationship between serum IgE level and CAVD was analyzed.
Results: Serum levels of IgE in CAVD group was significantly higher than Non-CAVD group 113.30 IU/ml vs 63.76 IU/ml (P<0.05); multivariate logistic regression analysis conifrmed above difference (P<0.05) and it also indicated that the alteration of surum IgE level is obviously related to CAVD occurrence.
Conclusion: Serum IgE level is obviously increased in CAVD patients. IgE is an independent biochemical indicator of CAVD, it may play the important role in CAVD pathogenesis.