Correlation of serum thyroid-stimulating hormone with dyslipidemia in subjects with normal thyroid function
10.3760/cma.j.issn.1000-6699.2016.01.005
- VernacularTitle:正常甲状腺功能人群血清促甲状腺素与血脂异常的相关性
- Author:
Ying HU
;
Lixin SHI
;
Qiao ZHANG
;
Nianchun PENG
- Publication Type:Journal Article
- Keywords:
TSH;
Dyslipidemia
- From:
Chinese Journal of Endocrinology and Metabolism
2016;(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum thyroid-stimulating hormone ( TSH) and dyslipidemia. Methods A total of 1 512 inhabitants in Zhaiji community of Guiyang urban areas were investigated from November 2009 to February 2010 by adopting stratified cluster sampling method, and 1 428 subjects were included in the present study. All subjects were asked to fulfill the questionnaires and to pass a physical examination. The vein blood samples were taken for determination of serum TSH, fasting plasma glucose (FPG), insulin, as well as blood lipid levels. Results Triglyceride ( TG ) , total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels were significantly increased in woman with subclinical hypothyroidism(SCH) compared to those with euthyroid(all P<0. 05). However, there was no significant difference in man between two groups(P>0. 05). The incidences of hypertriglyceridemia in the euthyroid group from quartile 1 toquartile4ofTSHwere33.3%,35.5%,39.7%,and44.0% respectively(P<0.05). SerumTGlevelwas increased with TSH in woman and total subjects after adjustment for age, sex, body mass index ( BMI) , waist-hip ratio (WHR), and homeostasis model assessment for insulin resistance index(HOMA-IR, P<0. 05). Serum TSH levels in the total sample were positively associated with TG after adjustment for age, sex, BMI, WHR, and HOMA-IR (β=0. 088,P<0. 05). Conclusion Higher serum TSH levels even within normal range seems to be a risk factor of dyslipidemia.
