The value of shear wave elastography for differential diagnosis of benign and malignant thyroid nodules
10.3760/cma.j.issn.1004-4477.2015.12.009
- VernacularTitle:实时剪切波弹性成像鉴别甲状腺结节良恶性的应用价值
- Author:
Fen WANG
;
Yi GAO
;
Yaling CHEN
;
Min CHEN
;
Cai CHANG
- Publication Type:Journal Article
- Keywords:
Elasticity imaging techniques;
Thyroid nodule
- From:
Chinese Journal of Ultrasonography
2015;(12):1047-1050
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of shear wave elastography (SWE)for differential diagnosis of benign and malignant thyroid nodules.Methods A total of 1 56 patients referred for surgery of thyroid nodules underwent standard ultrasound as well as elastography.The following characteristics of all the nodules were assessed:location,size,shape,margin,echogenicity,calcification and blood flow.The SWE elasticity indices of maximum (Emax),mean (Emean),minimum (Emin),and standard deviation (Esd) were automatically calculated by the US system.Thresholds were calculated by receiver operating characteristic (ROC ) curve analysis.The diagnostic performance of conventional US and SWE were compared.Histopathologic examination was used as the reference standard.Results Among a total of 1 56 nodules,1 1 8 were malignant and 38 were benign.SWE elasticity indices were significantly higher in malignant than in benign nodules (P ≤0.001 ).Sensitivity and specificity for predicting malignancy were 83.9%,92.1 % respectively using Emean with a threshold of 32.1 kPa,the specificity was significantly higher than using conventional ultrasound (P <0.05 ).Area under the ROC curve (Az)of Emean was highest (0.880,95% CI:0.81 7,0.943),however the differences were not significant(P >0.05).Conclusions SWE provides higher specificity for predicting malignancy without losing sensitivity.
