Median effective dose of 0 5%ropivacaine for ultrasound-guided adductor canal saphenous nerve block
10.3760/cma.j.issn.0254-1416.2015.12.018
- VernacularTitle:0．5％罗哌卡因用于超声引导内收肌管隐神经阻滞的半数有效剂量
- Author:
Yan TAO
;
Tao XU
;
Yan ZHOU
;
Wei ZHANG
;
Geng WANG
;
Yun YUE
- Publication Type:Journal Article
- Keywords:
Amides;
Nerve block;
Dose-response relationship,drug;
Ultrasonography
- From:
Chinese Journal of Anesthesiology
2015;(12):1476-1477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the median effective dose ( ED50 ) of 0?5% ropivacaine for ul?trasound?guided adductor canal saphenous nerve block. Methods Twenty?three patients of both sexes, aged 18-45 yr, weighing 50-85 kg, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, scheduled for elective arthroscopic meniscectomy, received an ultrasound?guided adductor canal saphenous nerve block. After successful location, 0?5% ropivacaine was injected. The sensory block of the area in?nervated by the saphenous nerve was assessed by pin?prick test. The dose of ropivacaine was determined by up?and?down technique. The initial dose of ropivacaine was set at 18 ml. Each time the dose increased∕de?creased in the next patient according to whether or not the sensory block of the area innervated by the saphe?nous nerve was complete, and the ratio between the two successive doses was 1 ∶ 1?2. The ED50 and 95%confidence interval of 0?5% ropivacaine for adductor canal saphenous nerve block were calculated by probit analysis. Results The ED50 (95% confidence interval) of 0?5% ropivacaine for ultrasound?guided adduc?tor canal saphenous nerve block was 10?7 ( 8?8-12?2) ml. Conclusion The ED50 of 0?5% ropivacaine for ultrasound?guided adductor canal saphenous nerve block is 10?7 ml.
