The efficacy of antithymocyte globulin combined with cyclosporine immunosuppressive therapy in the treat-ment of severe aplastic anemia

VernacularTitle:抗胸腺细胞球蛋白联合环孢素治疗重型再生障碍性贫血的疗效观察
Author: Xinhua WU ; Liwei WANG ; Chengda YUAN
Publication Type:Journal Article
Keywords: Anemia,aplastic anemia; Anti globulin; Cyclosporine
From: Chinese Journal of Primary Medicine and Pharmacy 2016;(1):71-73
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of anti thymic globulin (ATG)combined with cyclosporine (CSA)immunosuppressive therapy in patients with severe aplastic anemia (SAA).Methods 20 patients with SAA were treated with CSA combined with immunosuppressive therapy,and the changes of blood indexes after treatment were observed.Results After treatment,4 cases (13.33%)were cured,11 cases (36.67%)were relieved,8 cases (26.67%)were improved,7 cases (23.33%)were ineffective,the total effective rate was 76.67%.After the treatment of blood routine,examination of Hb,WBC and PLT treatment 6 months compared with before treatment,the difference were statistically significant (t =5.678,3.675,7.685,all P <0.05).Patients after treatment,1 case had allergic reaction,which accounted for 3.33%,and was finally given the glucocorticoid,then improved.1 case had extremely low WBC,accounting for 3.33%,appeared serious infection and death after testing.Conclusion The effect of ATG combined with CSA immunosuppression in the treatment of SAA is effective obviously,and it has a certain safety,vwhich is worthy of clinical recommendation.