Role of noncoding RNA in vascular injury, remodeling and aging
10.3969/j.issn.1001-1978.2016.01.004
- VernacularTitle:非编码 RNA 在血管损伤、重塑和老化中的作用
- Author:
Jing MA
;
Shuang LING
;
Yanqi DANG
;
Rongzhen NI
;
Huining GUO
;
Yufeng LI
;
Shurong WANG
;
Jinwen XU
- Publication Type:Journal Article
- Keywords:
MicroRNA;
lncRNA;
vascular injury;
vascular re-modeling;
vascular aging;
diseases of vascular system
- From:
Chinese Pharmacological Bulletin
2016;(1):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Non-coding RNAs ( ncRNA ), including ribosomal RNA( rRNA), transfer RNA( tRNA), MicroRNA ( miRNA), long noncoding RNA(lncRNA) and small nucleolar RNA(snoR-NA), are a class of RNA that have multiple functions and are not translated to proteins. MicroRNA and lncRNA are involved in the injury, remodeling and aging of blood vessels, and it is necessary to understand the regulatory roles of MicroRNA and lncRNA in these processes. It is reported that MicroRNA and lncRNA are not only participated in the regulation of oxidative response, inflammation, cell proliferation and migration, and phenotype transition, they are also involved in the regulation of gene expression by conducting different mechanisms, including transcriptional regulation, post-transcriptional modification and chromatin remodeling. These aspects of regulation by MicroRNA and lncRNA are related to cardiovascular diseases, such as ath-erosclerosis, hypertension, myocardial infarction, stroke, pul-monary hypertension and diabetes, and thus provide a new way for genetic diagnosis and therapy of cardiovascular diseases.
