Clinicopathalogical Differences of Immunofluorescent Staining Results in Lupus Nephritis Patients with Various Syndrome Patterns
10.13359/j.cnki.gzxbtcm.2016.01.005
- VernacularTitle:狼疮性肾炎不同中医证型免疫荧光病理的差异探讨
- Author:
Shaojie ZHANG
;
Shuifu TANG
- Publication Type:Journal Article
- Keywords:
lupus nephritis;
immunofluorescence;
syndrome patterns
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2016;(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the differences of immunofluorescence pathological test results in four types of syndromes for lupus nephritis(LN) patients. Methods A retrospective study was carried out in 116 LN patients who had performed renal biopsy. The patients were differentiated into four syndrome patterns of excessive heat-toxicity, liver-kidney yin deficiency, qi-yin deficiency, and spleen-kidney deficiency. The results of immunofluorescence pathological tests were recorded for the analysis of the differences among the four patterns. Results (1)Of 116 LN patients, 59 were classified into spleen-kidney deficiency, 30 into excessive heat-toxicity, 14 into liver-kidney yin deficiency, and 13 into qi-yin deficiency. (2)The positive expression rate of IgA, IgG, IgM, C3, and Fi fluorescen ce antibody differed in the 4 syndrome patterns of LN patients(P<0.05), IgA and C3 had higher positive expression rate, while Fi had the lowest expression rate. (3)The percentage of“full-house” immunofluorescence staining(5 kinds of antibodies simultaneously showing positive immunofluorescence staining) differed in the 4 syndrome patterns of LN patients(P<0.05), and excessive heat-toxicity syndrome had the highest percentage. (4)The differences of positive rate of immunofluorescence staining were insignificant in the 4 syndrome patterns of LN patients(P>0.05). Conclusion The immune complex deposition in LN patients is dominated by IgA and C3 antibodies deposition, and the“full-house” immunofluorescence staining is commonly seen in the syndrome of excessive heat-toxin type. But the results of immunofluorescence pathological tests can not be used as the evidence to tell the differences in the 4 syndrome patterns of LN patients.
