Effect of Biling Zhidai Tablets on Serum Levels of Monocyte Chemotactic Protein-1, Intercellular Adhesion Molecule-1 and Tumor Necrosis Factor-alpha in Rats with Sequela of Pelvic Inflammatory Diseases
10.13359/j.cnki.gzxbtcm.2016.01.022
- VernacularTitle:萆苓止带片对盆腔炎性疾病后遗症大鼠血清MCP-1、 ICAM-1及TNF-α表达的影响
- Author:
Zhixia CHEN
;
Siying ZOU
;
Cong WANG
;
Enshan PAN
;
Jianling HUANG
- Publication Type:Journal Article
- Keywords:
Biling Zhidai Tablets/pharmacology;
sequela of pelvic inflammatory diseases/TCD therapy;
inflammatory factors;
hemorheology;
disease models,animal;
rats
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2016;(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Biling Zhidai Tablets(BZT) on monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1)and tumor necrosis factor-alpha(TNF-α)levels as well as hemorheology of rats with sequela of pelvic inflammatory diseases(SPID). Methods One hundred Wistar rats were randomly divided into normal control group , sham-operation group , model group , BZT group(0.54 g·kg-1·d-1)and Fuke Baidai Tablets group(0.225 g·kg-1·d-1), 20 rats in each group . The rats of the model group, BZT group and Fuke Baidai Tablets group were given mechanical damage plus injection of mixed bacteria to induce SPID. After modeling for 2 weeks, the latter three groups were given intragastric administration of the medicine for 21 days. The uterine swelling rate, the serum levels of MCP-1, ICAM-1, TNF-α as well as hemorheological indexes of rats in various groups were detected. Results The uterine swelling rate in BZT group and Fuke Baidai Tablets group was significantly decreased as compared with that of the model group, and the uterine swelling inhibition rate of BZT group was higher than that of Fuke Baidai Tablets group (P<0.01). The levels of MCP-1, ICAM-1 and TNF-α of BZT group and Fuke Baidai Tablets group were significantly decreased as compared with those of the model group, and the effect of BZT group was better than t hat of Fuke Baidai Tablets group, the differences being statistically significant(P<0.05or P<0.01). The indexes of hemorheology in BZT group were significant improved as compared with Fuke Baidai Tablets group, and the improvement in BZT group was superior to that in Fuke Baidai Tablets group (P<0.05 or P<0.01). Conclusion B ZT e xert certain therapeutic effect on treating SPID rats, and the mechanism is related with the relief of swelling of uterus, decrease of serum MCP-1, ICAM-1 and TNF-αlevels and improvement of the indexes of hemorheology.
