Mesenchymal stem cells promote articular cartilage repair and regeneration
10.3969/j.issn.2095-4344.2015.50.028
- VernacularTitle:间充质干细胞促进关节软骨的修复与再生
- Author:
Yuqi ZHU
;
Jinrong WANG
;
Zhiyao WANG
- Publication Type:Journal Article
- Keywords:
Cartilage,Articular;
Stem Cels;
Mesenchymal Stem Cel Transplantation;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2015;(50):8195-8200
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:After articular cartilage injury, the injured cartilage almost has no self-healing ability. Articular cartilage injury repair has been always a difficulty in clinical work.
OBJECTIVE:To explore the types and biological characteristics of stem cels for articular cartilage repair and to ensure the role and relative merits of stem cel transplantation in articular cartilage repair.
METHODS:PubMed and CNKI were retrieved by the first author for relevant articles published from 1998 to 2015 using the keywords of “articular cartilage injury, mesenchymal stem cels, regeneration” in English and Chinese, respectively. Finaly, 47 articles were included in result analysis.
RESULTS AND CONCLUSION: Stem cel therapy is the most effective method for repair of articular cartilage injury. Mesenchymal stem cels from bone marrow, adipose and umbilical cord have strong chondrogenic and cloning capacities. Bone marrow mesenchymal stem cels have a stronger differentiation potential, and can be used for repair of cartilage injury. Umbilical cord-derived mesenchymal stem cels have a low tumorigenicity. Adipose-derived stem cels can proliferate and grow faster. Stem cels combined with natural carrier materials, such as colagen, gelatin, fibrin and alginate, can promote cel adhesion, differentiation and proliferation, in order to build an effective tissue engineered cartilage for repair of articular cartilage defects.
