Application of MR stem cell markers in research of temozolomide intervention gliomas angiogenesis and therapy
- VernacularTitle:MR干细胞标记在替莫唑胺干预脑胶质瘤血管生成及治疗研究中的应用
- Author:
Weizhi CHEN
;
Zhongheng YANG
- Publication Type:Journal Article
- Keywords:
MR;
stem cell markers;
glioma;
angiogenesis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(12):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of MR stem cell markers in temozolomide intervention gliomas angiogenesis and therapy .Methods C6 glioma cells were intravenously injected in glioma model rat.MR stem cell markers and immunohistochemistry were used to observe the tumor growth and angiogenesis.Correlation of contrast imaging and immunohistochemistry results were studied.Results In this study, MR scanning was successfully used to trace the SPIO-PLL marked bone marrow stem cells, dynamic testing of angiogenesis in rat brain glioma tumor.Correlation analysis of imaging and immunohistochemical showed that they had a good negative correlation (P<0.05).Conclusion SPIO magnetic markers for bone marrow stem cells and MR tracing technique is an effective means of dynamic observation in vivo glioma angiogenesis.
