Effect of N -acetylcysteine in adjunctive treatment of neonatal bronchopneumonia and its influence on serum inflammatory factors
10.3760/cma.j.issn.1008-6706.2016.01.003
- VernacularTitle:N-乙酰半胱氨酸辅助治疗新生儿支气管肺炎疗效及对血清炎性指标的影响
- Author:
Jiangang CHANG
- Publication Type:Journal Article
- Keywords:
N -acetylcysteine;
Baby,newbow;
Bronchopneumonia;
Tumor necrosis factor -α;
Interleukin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of N -acetylcysteine(NAC)in adjunctive treatment of neonatal bronchopneumonia and its influence on serum inflammatory factors.Methods 62 neonatus with bronchopneumonia treated in our hospital from June 2012 to December 2014 were randomly divided into observation group(32 cases)and control group(30 cases)with random number table.The control group was treated with basic therapy,such as relieving a cough and asthma,defervescing,oxygen inhalation,keeping respiratory tract unobstructed,nutritional support,while the observation group was added aerosol inhalation of NAC on the basis of basic therapy.Then the effect of the average time of body temperature returned to normal,the disappearance time of cough,asthma and pulmonary rale,and average hospitalization days of two groups were observed and compared,the levels of serum tumor necrosis factor -α(TNF -α), interleukin -1(IL -1),interleukin -6(IL -6)and interleukin -10(IL -10)of the two groups before and after treatment were detected.Results The total effective rate of the observation group was 90.63%,which was higher than 70% of the control group (χ2 =4.220,P <0.05).The average time of body temperature returned to normal, disappearance time of cough asthma and pulmonary rale,and average hospitalization days of the observation group were shorter than those of the control group (t =-4.211,-3.472,-4.240,-5.413,-7.822,all P <0.05).The levels of serum TNF -α,IL -1,IL -6 and IL -10 of the observation group after treatment were lower than those of the control group (t =-6.421,-3.892,-15.452,-9.773,all P <0.05).Conclusion Using aerosol inhalation of NAC in adjunctive treatment of neonatal bronchopneumonia can significantly improve the clinical effect and shorten the course of disease,meanwhile,it will eases the systemic inflammatory response to damage the organs by regulating the level of inflammatory factors,which is good for the recover of neonatus as soon as possible.
